University of Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK. j.evans@beatson.gla.ac.uk. Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan. David Geffen School of Medicine, UCLA Medical Center, Los Angeles, CA, USA. Severance Hospital, Yonsei University, Seoul, South Korea. National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei, Taiwan. Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan. Former employee of Eisai Ltd, Hatfield, UK. Eisai Inc., Woodcliff Lake, NJ, USA. Unit of Internal Medicine, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy. Tisch Cancer Institute at Mount Sinai, New York, NY, USA.